منابع مشابه
Integrin A6 Cleavage in Mouse Skin Tumors.
We have previously identified a structural variant of the α6 integrin (Laminin receptor) called α6p. The α6p variant is a 70 kDa form of the full-length α6 integrin (140 kDa) that remains paired with either the β1 or β4 subunit on the cell surface. α6p is produced by urokinase-type plasminogen activator (uPA), which removes the extracellular β-barrel domain while the receptor is on the cell sur...
متن کاملCD151 restricts the a6 integrin diffusion mode
Xiuwei H. Yang*, Rossen Mirchev, Xinyu Deng, Patrick Yacono, Helen L. Yang, David E. Golan and Martin E. Hemler Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536-0298, USA...
متن کاملb1- and a6-integrin are surface markers on mouse spermatogonial stem cells
Although spermatogenesis is essential for reproduction, little is known about spermatogonial stem cells. These cells provide the basis for spermatogenesis throughout adult life by undergoing self-renewal and by providing progeny that differentiate into spermatozoa. A major impediment to our understanding of the biology of these stem cells is the inability to distinguish them from spermatogonia ...
متن کاملKeratin gene expression in mouse skin tumors and in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate.
Alterations in the pattern of epidermal differentiation and proliferation occur during mouse skin carcinogenesis. We have used cDNA clones corresponding to the major keratin subunits synthesized in differentiating epidermal cells (Mr 67,000 and 59,000) and in proliferating epidermal cells (Mr 60,000, 55,000, and 50,000) to study changes in keratin gene transcript levels in mouse epidermis expos...
متن کاملUltraviolet radiation-induced inflammation activates β-catenin signaling in mouse skin and skin tumors.
UVB-induced inflammation, in particular the overexpression of cyclooxygenase-2 (COX-2) and prostaglandin (PG) E2, has been implicated in photocarcinogenesis. UVB-induced COX-2 has been associated with β-catenin signaling in keratinocytes. However, a definitive role for COX-2 in the activation of β-catenin signaling as well as its role in UVB-induced skin tumors has not been established. We repo...
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ژورنال
عنوان ژورنال: The Open Cancer Journal
سال: 2008
ISSN: 1874-0790
DOI: 10.2174/1874079000802010001